Pesquisa sobre:
ENHANCER OF ZESTE HOMOLOG 2 PROTEIN
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DeCS
Descritor
Inglês
:
Enhancer of Zeste Homolog 2 Protein
Descritor
Espanhol
:
Proteína Potenciadora del Homólogo Zeste 2
Descritor
Português
:
Proteína Potenciadora do Homólogo 2 de Zeste
Sinônimos
Inglês
:
Enhancer of Zeste Homolog 2
Histone-Lysine N-Methyltransferase EZH2
Lysine N-Methyltransferase-6
EZH2, Histone-Lysine N-Methyltransferase
Histone Lysine N Methyltransferase EZH2
Lysine N Methyltransferase 6
Categoria:
D05.500.781.750.250
D08.811.913.555.500.800.400.500.500
D12.776.660.235.600.200.250
D12.776.664.235.800.200.250
D12.776.930.780.890.200.250
Definição
Inglês
:
A
histone-lysine N-methyltransferase
and catalytic subunit of
Polycomb Repressive Complex 2
. It methylates
LYSINE
9 (H3K9me) and
LYSINE
27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone
proteins
such as
GATA4 TRANSCRIPTION FACTOR
and the nuclear receptor RORA. It regulates
CIRCADIAN CLOCKS
via histone
methylation
at the PROMOTER REGIONS of the circadian genes and its repressive activity is also important for the identity and differentiation of
EMBRYONIC STEM CELLS.
Nota Histórica
Inglês
:
2017 (2005)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56434
Identificador Único:
D000071221
Ocorrência na BVS
:
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CID-10
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